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However, when testosterone is administrated for 6 months AR expression returns to pretreatment levels (Ferrando et al. It has been suggested that the expression of AR can reach a steady state in response to the treatment paradigm (Ferrando et al. Altogether these results show the complexity of AR regulation in human skeletal muscle both under physiological and supraphysiological conditions. Satellite cells express androgen receptors The effect of testosterone on satellite cells is supported by the immunological detection of AR in porcine myogenic satellite cells in vitro (Doumit et al. Furthermore, immunoreactive AR increased in response to testosterone treatment (Doumit et al. Thus, satellite cells are direct targets for testosterone action.
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